2024年9月嘲风作品集（二）

▲ Vol34 Issue36 | 04 September, 2024

Chemokine-Based Injectable Navigation System for Enhancing CAR-T Cell Therapy Against Solid Tumors

Wenjun Wan, Wenqing Han, Jin Chen, Yangjing Li, Lei Zhao, Mengqian Gao, Cui Shen, Ning Liu, Wenhao Deng, Siqi Ma, Lifang Cheng, Yiran Zheng

CAR-T Cell Therapy

In article number2401161, Yiran Zheng and co-workers present a chemokine-based Injectable platform for boosting adoptive T cells’ efficacy (CITE). The system substantially promotes the tumor-specific migration of injected CAR-T cells and boosts the function of infiltrated T cells, thus improving the efficacies of CAR-T cell therapy to solid tumors. CITE also enhances systemic anti-tumor immunity and elicits immune memory, enabling CITE to treat multimodal and recurrent tumors. CITE is broadly applicable to adoptive cell therapies.

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202470209

▲ Vol34 Issue36 | 04 September, 2024

Supramolecular Electronics: Monolayer Assembly of Nonamphiphilic Molecules via Water Surface-Assisted Molecular Deposition

Jun Lim, Chuanhui Liu, Xiao Han, Menghan Tian, Baichuan Jiang, Wenbin Li, Cailing Ou, Nannan Dou, Zixiao Han, Tingyu Ji, Xiaoru Cao, Xiaolan Zhong, Lei Zhang

Utilizing softly confined self-assembly at the water surface represents a promising approach for the fabrication of two-dimensional molecular monolayers (2D MMs), which have predominantly been concentrated on amphiphilic organic compounds before. Herein, we introduce a straightforward method termed “water surface-assisted molecular deposition (WSAMD)” to organize nonamphiphilic molecules into dense monolayers with high reproducibility. To underscore the versatility and merit of this methodology in the field of supramolecular electronics, we have successfully fabricated a range of defect-free, uniform semiconducting polymer monolayers, featuring a thickness reflective of molecular architectures. The charge carrier mobility could reach 0.05 cm2V–1s–1for holes and 3.5 × 10–4cm2V–1s–1for electrons, respectively, in p-type and n-type polymeric monolayers when tested as the active layer in field-effect transistors. Furthermore, in situ polymerization reactions can be exploited to generate conductive monolayers of macromolecules such as polybenzylaniline (PBnANI) and polypyrrole (PPy), where PBnANI monolayers exhibit channel length-dependent conductivity, up to 0.37 S cm–1. The advent of the WSAMD method heralds a significant leap forward in the advancement of molecular 2D materials, catalyzing new avenues of exploration within material chemistry.

https://pubs.acs.org/doi/10.1021/acsami.4c05552

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